Endocrine Abstracts

Raloxifene is a new selective estrogen modulator. It has been shown to prevent bone loss and to reduce vertebral fracture risk in postmenopausal women. This study was designed to investigate effects of raloxifene and oestradiol on bone formation and resorption in intact and ovariectomized (ovx) rat models. In the intact model, a total of 24 adult female rats were divided into three groups: Controls subcutaneously received saline alone. Raloxifene (2 mg/kg) and oestradiol (30 m...

We have investigated the effects of estradiol valerat plus dienogest and raloxifene on serum high sensitive C - reactive protein (hsCRP) levels in healthy postmenopausal women. This study was approved by the local ethics committee. Forty eight healthy postmenopausal women were randomly divided into three groups. While group I (n=16) was given 60 mg raloxifene, group II (n=16) received continuously 2 mg estradiol valerat plus 2 mg dienogest. Group III (n=16) received no medicat...

This study was designed to investigate effects of raloxifene treatment on serum interleukin (IL)-4 and transforming growth factor-beta (TGFbeta)1 concentrations in healthy postmenopausal women. The study was approved by the local ethics committee. Thirty five women were enrolled into this study and randomly divided in two groups. While 16 women were included in raloxifene group, control group was comprised of remaining 19 women. The study group continuously received 60 mg ralo...

Ghrelin, a recently isolated hormone, has been reported to have modulatory effects on smooth muscle contractility. In this study, we investigated the effects of ghrelin on spontaneous contractions in the rat uterus in vitro.Myometrium strips were removed from Wistar rats following decapitation and placed in a jacked tissue bath containing Krebs solution at 37 oC and pH 7.4, constantly bubbled with 95% oxygen and 5% carbon dioxide. The myometrial strips w...

Nebivolol is a recently developed beta(1)-selective adrenergic receptor antagonist with proposed nitric oxide mediated vasodilating properties. Effect of nebivolol on vascular smooth muscle has been attributed to estrogen receptor-mediated vascular responsiveness. Although it is known that nitric oxide has relaxing effect on myometrium, there is no report whether nebivolol application affect myometrial contractility. Therefore, we have investigated the effect of nebivolol on r...